Ristenza’s® patented formulation is crafted from three FDA-approved drugs (Tramadol, Dextromethorphan and Sildenafil), designed to work together synergistically to target the eight key receptors involved in ejaculation. This unique combination helps you gain more control over your experience while maintaining the same level of intimacy and connection with your partner. Ristenza® stands out as the premier, targeted therapy for Early Climax.

Before Ristenza®, the medical approaches to premature ejaculation were limited and often ineffective:

SSRIs (Antidepressants): While sometimes prescribed for PE, SSRIs are not specifically designed to treat it. They often require daily use and can come with a range of undesirable side effects.

PDE-5 Inhibitors (Erectile Dysfunction Medications): These drugs are FDA-approved to treat erectile dysfunction, but they do not address premature ejaculation or improve timing control.

Topical Gels/Creams: While these products can reduce sensitivity, they often result in a numbing effect that may lead to difficulty maintaining an erection and a diminished sense of pleasure. Application can also be messy, inconvenient, and may cause irritation or burning sensations.

Kegel Exercises: While these exercises can help strengthen pelvic muscles, they are not a proven solution for PE. On their own, they cannot provide the level of control and intimacy that Ristenza® offers.

Ristenza® goes beyond these traditional approaches by offering a proven, science-backed solution tailored specifically for premature ejaculation. With high levels of success reported by hundreds of users, Ristenza® empowers you to experience deeper intimacy and confidence in your relationship.

If you have any questions or concerns, feel free to reach out to us at support@ristenza.com. When you contact us, you’ll speak directly with a knowledgeable and understanding Ristenza® representative based in the United States. We respect your time and privacy—you won’t receive any spam emails from us.

We look forward to helping you take the next step toward greater intimacy and control.

Yes, Ristenza® is safe. Unlike daily medications, Ristenza® is taken on-demand, reducing overall exposure and minimizing the risk of side effects or dependency.

One of Ristenza’s key ingredients, Tramadol, has a lower risk of addiction compared to traditional opioids. Numerous studies like the one in the National Institutes of Health’s PubMed Central, notes that the risk of addiction is significantly reduced when Tramadol is used intermittently and at appropriate doses (PMC3821202).

Because Ristenza® is only prescribed after an online consultation with a licensed physician, you can feel confident in its safety and effectiveness. If you have any concerns, our medical team is here to help to contact email support@ristenza.com. To date, we’ve had no reports of serious side effects; one patient noted mild acid reflux and continued therapy. As with any prescription medication—especially those containing tramadol—individual risks exist, so use only as directed and contact our clinicians with any concerns.

Ristenza's® revolutionary formula operates by regulating the receptors responsible for delaying ejaculation, contributing to enhanced endurance during sexual activity. The key lies in the synergy of our three primary ingredients, each meticulously dosed for maximum efficacy. While these ingredients have demonstrated individual effectiveness in delaying ejaculation, higher doses often result in undesirable side effects. Ristenza® innovatively addresses this challenge by skillfully combining the three ingredients at significantly lower doses, ensuring effective outcomes without compromising safety. While we cannot guarantee extreme effectiveness for every single patient, we have seen extremely good results with both the RDT, and Pill formulations. In addition, we have not reported any side effects

For more scientific research, or questions please visit our clinical data tab, or email support@ristenza.com to be connected to our medical team who can explain in-depth the development, and effectiveness of Ristenza®.

Tramadol is a prescription analgesic that also modulates serotonin and norepinephrine pathways. In low, on-demand doses, it can help delay climax in some men by dampening the ejaculatory reflex and reducing hypersensitivity. It’s used in Ristenza® under physician oversight and should be taken exactly as prescribed.

When used together with sildenafil and dextromethorphan, the components may act synergistically—addressing arousal, sensitivity, and timing—to help reduce premature ejaculation for appropriate patients.

Safety note: Tramadol can cause drowsiness, nausea, or dizziness and may interact with medicines that affect serotonin (e.g., certain antidepressants). Do not use with alcohol or sedatives. Your clinician will confirm if it’s appropriate for you.

Dextromethorphan (DXM) is an FDA-approved cough suppressant found in many OTC products. At the low, on-demand dose used in Ristenza®, it also modulates brain pathways involved in timing and sensitivity—primarily through NMDA receptor antagonism and sigma-1 receptor effects. By dampening the central ejaculatory reflex.

Sildenafil (the active ingredient in Viagra®) is an FDA-approved PDE5 inhibitor that increases blood flow to the penis, helping you get and maintain a firmer erection. While sildenafil isn’t a PE drug by itself, improving erection quality can reduce the “rush-to-finish” cycle and performance anxiety that often worsen premature ejaculation. In Ristenza®, sildenafil supports arousal and firmness while tramadol and dextromethorphan help with timing and sensitivity, creating a complementary, on-demand approach.

Given that Ristenza® contains Sildenafil, which assists in achieving and maintaining an erection, it is recommended to skip your Sildenafil or Tadalafil on days you use Ristenza®. Ristenza® contains 42.2 MG of Sildenafil Citrate.

Ristenza® is compounded in the United States by a state-licensed compounding pharmacy. Our partner pharmacy maintains accreditations from URAC, ACHC-PCAB, and LegitScript, reflecting adherence to nationally recognized quality and safety standards.

Because Ristenza® is prepared specifically for each prescription, we do not publish the pharmacy’s details on the website. The dispensing pharmacy’s name, address, and contact information appear on your prescription label and receipt, as required by law.

Shipping, tax, and your online doctor consultation are included in the price on our order now page. No hidden fees what you see is what you will pay.

• With dry hands, place one Ristenza® ODT/RDT on your tongue and let it fully dissolve (usually ~8 seconds). No water is needed—don’t chew or crush.

• Take 30–60 minutes before sexual activity. Many patients find a light/empty stomach helps it work faster; heavy or high-fat meals can delay onset.

• Avoid alcohol (can increase dizziness/sedation) and do not use nitrates or riociguat. If you take SSRIs/SNRIs, MAOIs, migraine meds, or other serotonergic drugs, use only under clinician guidance. All current medications are stated on medical intake form, and prescribing physician reviews before your online consultation.

• Keep tablets in the blister until use and store in a cool, dry place.

Prefer a swallowable pill?
On request (support@ristenza.com), Ristenza® can be compounded as a traditional tablet instead of ODT/RDT. Talk with your clinician—formulation can affect onset time and what’s right for you.

Yes, you will need a prescription from a healthcare provider which by completing order/shipping, and medical intake form you will select the date/time for your online consultation with a licensed United States physician.

Simply click the order now tab on the main navigation menu, and select your desired pack, or click here!

Effects lasts 6-8 hours after tablet is fully dissolved.

Once your online consultation is complete, your physician will begin the paperwork for your Ristenza® prescription—this usually takes around 1 day. From there, your prescription is submitted to our partner pharmacy, where it typically takes another 1 to 2 business days to compound and prepare your custom medication.

After that, your order is shipped via FedEx, with delivery typically within 5 business days—often sooner, depending on your location.

If you have your online consultation, and decide you would not like to try Ristenza® or at any time prior to receiving your medication please email support@ristenza.com, and a full refund will be given!

But, due to state laws and pharmacy regulations governing prescription medications, we are unable to accept returns for Ristenza® once your prescription has been formulated.

Ristenza® is currently available in 43 states. Please refer to the map on our homepage to see if Ristenza® is available in your state.

Simply click the refill link above, select which size of refill you would like, and enter you information! You will receive updates on the status of your refill.

Refills of Ristenza® do not require another doctor visit.

However, you are limited to a maximum of 16 tablets per 30 days.

Finally, Ristenza® can only be refilled up to 5 times within 6 months without another consultation.

We prioritize the security and privacy of your information. Our platform was developed with security protocols to safeguard your data, and it fully complies with all relevant privacy laws. For detailed information, please refer to our privacy policy for a comprehensive understanding of our commitment to protecting your data.

We are always open to speaking with new providers who are interested in offering Ristenza’s® patented formula to their patients. Please email us at info@ristenza.com, and we will connect you with our management team.

No, Ristenza® is a prescription medication specifically approved for individuals whose biological sex is male.

Women can place an order for Ristenza; however, the order must include their male partner's information. Additionally, he must be the one to complete the online consultation to receive a prescription.

Some of the possible effects include nausea, gastro-intestinal disturbances, drowsiness, dizziness, constipation, headache, vomiting, pruritus/itchiness, agitation, diarrhea, dry mouth, sweating, skin flushing, dyspepsia, prolonged erection, nasal congestion, abnormal or blurred vision, abnormal hearing, decreased memory, Serotonin Syndrome.

If you experience a side effect not listed above, please consult with your prescribing physician.

You will receive text messages showing the status of your order.

The FDA does not verify the safety or effectiveness of compounded drugs. However, all three ingredients in Ristenza's® patented formula are FDA approved drugs and have a long history of use, safety, and effectiveness for their primary indications. Prescription products require a consultation with a healthcare provider.

All of our medical providers are licensed board-certified physicians in the United States.

Upon completing the intake form on our website, you'll have the opportunity to specify a convenient time for our medical provider to contact you to complete your virtual consultation.

It is normal for the Ristenza® pill sachet to contain powder residue upon opening. Ristenza® is a rapid-dissolving tablet, and it lacks any coating to facilitate quick dissolution in the mouth. This absence of coating ensures a faster dissolution process, leading to quicker effectiveness of the pill.

Breakage can occur due to the composition of the Ristenza® tablet and shipping conditions. Ristenza® is a rapid-dissolving tablet without any coating to facilitate quick dissolution in the mouth. If breakage occurs, don't worry - simply take all the contents in the sachet for optimal results.

If you are not approved for Ristenza®, our medical provider will notify you during your virtual consultation, and your order will be canceled and refunded.

Our medical providers advise against taking Ristenza® while consuming alcohol.

Our medical providers advise against using illegal drugs, especially if taking Ristenza®.

Our medical providers strongly recommend waiting for a minimum of 30 minutes before smoking or vaping to ensure Ristenza® achieves complete absorption, enabling it to reach its maximum effectiveness.

Ristenza® includes Sildenafil, the primary ingredient in Viagra, known for aiding in achieving and sustaining an erection. Sildenafil is FDA approved for treating erectile dysfunction, functioning by enhancing blood flow to the penis.

Ristenza® is a rapid-dissolving tablet, and therefore is sensitive to light and moisture. To maintain the tablet's integrity, keep each sachet sealed until consumption. For optimal results, it is recommended to consume the tablet immediately after opening.

Ristenza® is a delicious wild berry flavor.

You are limited to a maximum of 16 tablets per 30 days.

Ristenza® can only be refilled up to 5 times within 6 months without another consultation.

Simply click the refill link above, and your prescription refill will be processed, and shipped.

Your Ristenza® medication will be shipped via FedEx.

Ristenza® is only available to ship to the residential address you provide. All shipping is taken care of on our end.

If you have a question for our pharmacy, please reach out to our dedicated customer service team at support@ristenza.com. We can answer any question you can think of!

Contact Customer Care by Email: support@ristenza.com

You will be contacted by a live representative within 24 hours. You will not receive or be signed up for promotional emails.