RISTENZA®

Below are the 3 hyperlinks to the patents on which the Ristenza® formulation was built upon.

  1. Method to treat premature ejaculation in humans. 
  2. Method to treat premature ejaculation in humans.
  3. Dextromethorphan hydrochloride.

Below are third party studies done on Ristenza® API’s.

On-demand use of tramadol, sildenafil, paroxetine and local anesthetics for the management of premature ejaculation: A randomized placebo-controlled clinical trial: (https://pubmed.ncbi.nlm.nih.gov/26558110/)

Tramadol Use in Premature Ejaculation: Daily Versus Sporadic Treatment: (https://pmc.ncbi.nlm.nih.gov/articles/l)

Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis: (https://pubmed.ncbi.nlm.nih.gov/30225547)

Phosphodiesterase Type 5 Inhibitors for Premature Ejaculation: A Systematic Review and meta-analysis: (https://pubmed.ncbi.nlm.nih.gov/28720356)

Efficacy and safety of phosphodiesterase type 5 inhibitors on primary premature ejaculation in men: (https://pubmed.ncbi.nlm.nih.gov/26791333/)

Tramadol for the Management of Premature Ejaculation: (https://www.nature.com/articles/ijir20157)

Safety and Efficacy of Tramadol Hydrochloride on Treatment of Premature Ejaculation: (https://pmc.ncbi.nlm.nih.gov/articles/PMC3739134/)

The Use of Tramadol “On-demand” for Premature Ejaculation: A Systematic Review: (https://www.goldjournal.net/article/S0090-4295(12)00980-6/abstract)

On-demand Tramadol Hydrochloride Use in Premature Ejaculation Treatment: 

(https://www.sciencedirect.com/science/article/abs/pii/S0090429511024459)

Tramadol is an Effective Therapy for Mild to Severe Premature Ejaculation: (https://www.nature.com/articles/nrurol.2011.138)